Brit. J. Anaesth. (1972), 44,1329 GENTAMICIN, TUBOCURARINE, LIGNOCAINE AND NEUROMUSCULAR BLOCKADE A Case Report

A 54-year-old male clerical worker was admitted to the unit on May 27, 1971, with intractable pulmonary oedema secondary to aortic regurgitation associated with bacterial endocarditis. Five years previously he had undergone a homograft valve replacement for calcine aortic stenosis. His treatment on admission consisted of cephaloridine 1 g 6-hourly intravenously, digoxin 0.25 mg 8hourly, frusemide 80 mg 12-hourly and potassium chloride supplements (Slow K) 1200 mg 6-hourly. The aortic homograft was successfully replaced by a No. 9 StarrEdwards prosthesis on the following day. Pancuronium 20 mg was used during the procedure (0.26 mg/kg weight) and its effect was fully reversed after injection of atropine 1.2 mg and neostigmine 5 mg intravenously. The early postoperative course was very satisfactory. Parenteral cephaloridine was continued and small doses of diazepam (5—10 mg i.v.) and morphine (5 mg i.v.) were necessary for sedation and analgesia.